Like NA27, this is the leading edition of the original text of the New Testament. It contains the same Greek text as NA27, differing only in some details of punctuation and paragraphing. The format of UBS4 is in several respects more user-friendly for students and translators than NA27. It has a more spacious appearance and a larger font. English sub-headings assist in navigating the text for those who may be less familiar with Greek. Old Testament quotations appear in easily recognizable bold font. Synoptic parallels are clearly listed under English headings.

The critical apparatus includes exegetically significant variants (fewer than NA27) but adds extensive manuscript evidence (more than NA27) for each variant, thereby offering in-depth instruction for students on how variants and the evidence for them work together.

An introduction in English is included.